The first BactiVax publication is out now

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Two months through his project, Samuel Pasco, our Project 7 Researcher has just published a review article in Cells. His paper reflects on lessons learnt from the Bacillus Calmette-Guérin (BCG) vaccine, the only approved vaccine against Mycobacterium tuberculosis (Mtb). While BCG vaccination does not confer absolute protection against Mtb, it does stimulate trained immunity that correlates with lower mortality and increased protection against unrelated pathogens. This review focuses on BCG-induced trained immunity, including the required pathways to establish this phenotype. Additionally, potential methods to improve BCG trained immunity effects are discussed, together with advances in new anti-Mtb vaccines and other antimicrobial uses for BCG.

Samuel Pasco and Juan Anguita. Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development. Cells 2020, 9(9), 2109; https://doi.org/10.3390/cells9092109.

 

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Congratulations to #BactiVax researchers @irenejm6, @maite_s96 and Assoc. Prof. Siobhán McClean on their recently published review on Pseudomonas aeruginosa #vaccine development! 🦠 P. aeruginosa is an antibiotic-resistant, hospital-acquired pathogen that can cause severe and difficult to treat infections. Link to open access paper here & in bio: https://t.co/l1y9Ugh5Sj?amp=1
🧪⚗ #EuropeanResearchersNight is here! Make sure to check some of the #cool #science events organised across Europe today, especially the @meetmetonight20 event in Milan, as #BactiVax will be there. Tonight @5pm CET & tomorrow @4pm CET, we'll have interactive sessions on #vaccine discovery, held by our Project 6 Researcher @_ritafranco and Prof. Francesco Peri @unimib. 🗒 Free registration: meetmetonight.it/programma/
BactiVax - Siobhán McClean